Front Pharmacol 14:1205207
Reasons for B12 deficiency with vegan diets and symptoms B12 is an essential vitamin that our body needs for many functions
The specific thresholds that should prompt dose reduction or discontinuation include: ALT or AST elevation exceeding 3 times the patient's baseline value, new or worsening coagulopathy (INR increase of 0.5 or more from baseline), albumin decline below 2.5 g/dL, or new clinical signs of hepatic decompensation such as worsening ascites, encephalopathy, or jaundice [5]
Co-induction of glutathione- S -transferases and multidrug resistance associated protein by xenobiotics in wheat
Nasal route is generally lower-risk for such issues but care must still be taken with formulation, preservation, and absorption variability
10.1080/10715769900301211 Free Radic